Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study.
Identifieur interne : 002512 ( Main/Exploration ); précédent : 002511; suivant : 002513Joint effect of mid- and late-life blood pressure on the brain: the AGES-Reykjavik study.
Auteurs : Majon Muller ; Sigurdur Sigurdsson ; Olafur Kjartansson ; Thor Aspelund ; Oscar L. Lopez ; Palmi V. Jonnson ; Tamara B. Harris ; Mark Van Buchem ; Vilmundur Gudnason ; Lenore J. LaunerSource :
- Neurology [ 1526-632X ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse de variance, Cognition (physiologie), Encéphale (anatomopathologie), Femelle, Humains, Hypertension artérielle (anatomopathologie), Hypertension artérielle (physiopathologie), Hypertension artérielle (épidémiologie), Imagerie par résonance magnétique, Islande (épidémiologie), Mâle, Pression sanguine (physiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Susceptibilité à une maladie, Tests neuropsychologiques, Vieillissement (anatomopathologie), Vieillissement (physiologie), Études rétrospectives.
- MESH :
- anatomopathologie : Encéphale, Hypertension artérielle, Vieillissement.
- physiologie : Cognition, Pression sanguine, Vieillissement.
- physiopathologie : Hypertension artérielle.
- épidémiologie : Hypertension artérielle, Islande.
- Adulte, Adulte d'âge moyen, Analyse de variance, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Susceptibilité à une maladie, Tests neuropsychologiques, Études rétrospectives.
- Wicri :
- geographic : Islande.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Aging (pathology), Aging (physiology), Analysis of Variance, Blood Pressure (physiology), Brain (pathology), Cognition (physiology), Disease Susceptibility, Female, Humans, Hypertension (epidemiology), Hypertension (pathology), Hypertension (physiopathology), Iceland (epidemiology), Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Retrospective Studies.
- MESH :
- geographic , epidemiology : Iceland.
- epidemiology : Hypertension.
- pathology : Aging, Brain, Hypertension.
- physiology : Aging, Blood Pressure, Cognition.
- physiopathology : Hypertension.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Disease Susceptibility, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Retrospective Studies.
Abstract
We hypothesized that in participants with a history of hypertension, lower late-life blood pressure (BP) will be associated with more brain pathology.
DOI: 10.1212/WNL.0000000000000517
PubMed: 24898928
Affiliations:
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Le document en format XML
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Lopez</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Jonnson, Palmi V" sort="Jonnson, Palmi V" uniqKey="Jonnson P" first="Palmi V" last="Jonnson">Palmi V. Jonnson</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Van Buchem, Mark" sort="Van Buchem, Mark" uniqKey="Van Buchem M" first="Mark" last="Van Buchem">Mark Van Buchem</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik. 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Lopez</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Jonnson, Palmi V" sort="Jonnson, Palmi V" uniqKey="Jonnson P" first="Palmi V" last="Jonnson">Palmi V. Jonnson</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Van Buchem, Mark" sort="Van Buchem, Mark" uniqKey="Van Buchem M" first="Mark" last="Van Buchem">Mark Van Buchem</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation><nlm:affiliation>From the Laboratory of Epidemiology and Population Sciences (M.M., T.B.H., L.J.L.), Intramural Research Program, National Institute on Aging, Bethesda, MD; the Departments of Gerontology and Geriatrics (M.M.) and Radiology (M.v.B.), Leiden University Medical Center; Icelandic Heart Association (S.S., O.K., T.A., V.G.), Kopovagur; the Departments of Neurology & Radiology (O.K.) and Geriatrics (P.V.J.), Landspitali National University Hospital, Reykjavik, Iceland; the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and the Faculty of Medicine (P.V.J.), University of Iceland, Reykjavik. LaunerL@nia.nih.gov.</nlm:affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Aging (pathology)</term><term>Aging (physiology)</term><term>Analysis of Variance</term><term>Blood Pressure (physiology)</term><term>Brain (pathology)</term><term>Cognition (physiology)</term><term>Disease Susceptibility</term><term>Female</term><term>Humans</term><term>Hypertension (epidemiology)</term><term>Hypertension (pathology)</term><term>Hypertension (physiopathology)</term><term>Iceland (epidemiology)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Retrospective Studies</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de variance</term><term>Cognition (physiologie)</term><term>Encéphale (anatomopathologie)</term><term>Femelle</term><term>Humains</term><term>Hypertension artérielle (anatomopathologie)</term><term>Hypertension artérielle (physiopathologie)</term><term>Hypertension artérielle (épidémiologie)</term><term>Imagerie par résonance magnétique</term><term>Islande (épidémiologie)</term><term>Mâle</term><term>Pression sanguine (physiologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Susceptibilité à une maladie</term><term>Tests neuropsychologiques</term><term>Vieillissement (anatomopathologie)</term><term>Vieillissement (physiologie)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Iceland</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term><term>Hypertension artérielle</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hypertension</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term><term>Brain</term><term>Hypertension</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cognition</term><term>Pression sanguine</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term><term>Blood Pressure</term><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Hypertension artérielle</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypertension</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Hypertension artérielle</term><term>Islande</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Disease Susceptibility</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de variance</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Susceptibilité à une maladie</term><term>Tests neuropsychologiques</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Islande</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We hypothesized that in participants with a history of hypertension, lower late-life blood pressure (BP) will be associated with more brain pathology.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><name sortKey="Jonnson, Palmi V" sort="Jonnson, Palmi V" uniqKey="Jonnson P" first="Palmi V" last="Jonnson">Palmi V. Jonnson</name><name sortKey="Kjartansson, Olafur" sort="Kjartansson, Olafur" uniqKey="Kjartansson O" first="Olafur" last="Kjartansson">Olafur Kjartansson</name><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name><name sortKey="Muller, Majon" sort="Muller, Majon" uniqKey="Muller M" first="Majon" last="Muller">Majon Muller</name><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name><name sortKey="Van Buchem, Mark" sort="Van Buchem, Mark" uniqKey="Van Buchem M" first="Mark" last="Van Buchem">Mark Van Buchem</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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